Yerevan, 11.May.2021,
1 $ = 0 ֏, 1 = 0 ֏, 1 = 0 ֏

Scientists explain emergence of especially dangerous pathogens of tuberculosis


In a new study, published in the journal Bioorganic Chemistry, scientists have explained why Mycobacterium tuberculosis survives in inappropriate environmental conditions inside the human body.

The results of this study may help to better understand the role of enzymes in bacteria in the development of resistance against the human immune system and drugs.

The authors of the study examined the crystal structure and function of rubredoxin B (RubB), a metalloprotein (a protein containing metal atoms) that ensures the proper functioning of cytochrome P450, another protein important for bacterial survival. Scientists have a hypothesis, according to which, tubercle bacilli have learned to switch rubredoxin into a mode that ensures the effective use of iron in conditions of iron deficiency, which is observed during the formation of granulomas (nodules) in the lungs.

As a result, it turned out that rubredoxin B is associated with heme monooxygenases, which are important for the metabolism of oxysterols (they play a signaling role in the maintenance of immunity) and the host's anti-tuberculosis drugs. In other words, M. tuberculosis has the ability to neutralize xenobiotics.

Previous research has shown that one of the cytochromes supported by RubB may act against SQ109, a promising potential drug for multidrug-resistant tuberculosis.

According to the WHO, every year around the world 10 million people fall ill with tuberculosis, and 1.5 million people die from it, which makes it the main infectious killer in the world. Particularly dangerous strains of the tubercle bacillus, which have appeared in recent decades, have multiple drug resistance, mainly antibiotics, which greatly complicates the treatment of the infection.

Armenia President signs decree on calling snap parliamentary elections on June 20 Dwayne Johnson congratulates his wife on Mother's Day Israeli new president to be elected on June 2Biographer on Prince Harry’s interview with Oprah Winfrey Scientists find out why women under 50 develop bowel cancer Putin holds phone talks with Aliyev Iranian FM says Donald Trump is a 'disgraced buffoon' Erdogan: EU will not retain its power without Turkey Elon Musk says he has Asperger's syndrome Armenia President petitions to Constitutional Court Pregnant woman, 30, dies in Yerevan US-led coalition Iraqi base under attack George Clooney turns down Prince Harry invite to motorcycle ride Armenia has new deputy minister of high tech Azerbaijani Commissioner for Human Rights addresses letters to UN and CoE, complains about Armenia Ombudsman Armenia legislature convenes special session to consider new Electoral Code Dollar gains value in Armenia Can polio vaccine protect against COVID-19? Latvia parliament recognizes Armenian Genocide Ara Aivazian, Sergey Lavrov tête-à-tête kicks off (PHOTOS) Israel forming new Cabinet Zinc deficiency may increase risk of severe COVID-19, study claims Armenian footballer's goal helped Anorthosis beat AEL 2-1 Ombudsman - Killed Armenian soldiers, chained POWs’ park in Baku: Museum of human sufferings, promotion of racism "Stalin" wins India state elections Quake jolts Armenia Uday at Ucom online shop: Up to 60% discount for premium class “Nice” phone numbers and gadgets Man City-PSG: After first halfPrince Harry seen at concert with J.Lo, but without his pregnant Meghan Markle Footage: Metro train bridge collapse About 0.1% of Armenia residents is vaccinated against coronavirus Man City vs. PSG clash: Bookmakers’ view Armed person attempts to drive through CIA main entrance Armenian human rights activist: Out of captured persons, 19 have been tortured and killed by Azerbaijani servicemen Dollar devalues in Armenia Why do Parkinson's patients see ghosts? Premieres in May: Let's go to the cinema! ArmenՅԱՆs: Arthur Gourounlian does choreography for Pussycat Dolls, Beyonce, Kylie Minogue and etc. Is it safe for working out on an empty stomach? 145 new cases of COVID-19 confirmed in Armenia Britney Spears' father says his daughter has dementia Serj Tankian dedicates music video to his son and 13th century poet Quake hits Armenia Arman Tatoyan: Armenia Ombudsman's Office analyzed nearly 300 videos showing tortures of Armenians Why consuming omega-3 fatty acids may be dangerous? Royal Mint produces largest gold coin in history weighing 10 kg IDpay: transfers from Armenia to Russia and vice versaHenrikh Mkhitaryan: I keep in touch with Manchester United players One dollar drops below AMD 520 in Armenia Armenia acting Deputy PM receives Iran Ambassador